PRENYLATION INHIBITORS REDUCE HOST CELL PERMISSIVENESS TO VIRAL REPLICATION
摘要
Permissiveness of human cells to replication of susceptible pathogenic human viruses is reduced by treating the cells with a selective inhibitor of prenylation of a host cell protein. Target viruses, especially Flaviviridae, are predetermined to lack a CXXX box and prenylated viral protein, and to be replication-dependent on host protein prenylation. The general method comprises (a) contacting human cells subject to infection by the virus with an effective amount of a selective inhibitor of a prenylation enzyme of the cells; and (b) confirming a resultant reduction in permissiveness of the cells to replication of the virus. Targeted enzymes include prenyl biosynthetic enzyme like HMG CoA reductase farnesyl and/or geranylgeranyl transferase enzymes.
申请公布号
WO2005039503(A3)
申请公布日期
2006.08.31
申请号
WO2004US35362
申请日期
2004.10.21
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人
BROWN, MICHAEL, S.;YE, JIN;WANG, CHUNFU;SUMPTER, RHEA;GOLDSTEIN, JOSEPH, L.;GALE, MICHAEL