发明名称 |
Compositions of (-)-17-(Cyclobutylmethyl)Morphinan-3,14,-Diol |
摘要 |
The present invention is directed to oral, therapeutically effective modified release pharmaceutical compositions of (−)-17-(cyclobutylmethyl)morphinan-3,14-diol and it pharmaceutically acceptable salts and the use thereof, including delayed onset and extended release dosage forms. The present invention is also directed at modified release dosage forms of oral (−)-17-(cyclobutylmethyl)morphinan-3,14-dial which provide robust efficacy and reduced potential for abuse and misuse. |
申请公布号 |
US2016235740(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
US201615135985 |
申请日期 |
2016.04.22 |
申请人 |
BABUL Najib |
发明人 |
BABUL Najib |
分类号 |
A61K31/485;A61K9/50;A61K9/00 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
1. An oral dosage form comprising: (i) a therapeutically effective amount of butorphanol, a pharmaceutically acceptable salt thereof, or a mixture thereof, and (ii) controlled release material to release the butorphanol from the dosage form substantially only distal to the stomach following oral administration of the dosage form. |
地址 |
Blue Bell PA US |