发明名称 |
Controlled Delivery System |
摘要 |
The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. |
申请公布号 |
US2016235726(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
US201615005937 |
申请日期 |
2016.01.25 |
申请人 |
Durect Corporation |
发明人 |
Verity Adrian Neil |
分类号 |
A61K31/445;A61K47/26;A61K47/22;A61K9/00 |
主分类号 |
A61K31/445 |
代理机构 |
|
代理人 |
|
主权项 |
1. A composition comprising an anesthetic and a pharmaceutically acceptable non-polymeric carrier, wherein the non-polymeric carrier controls release of the anesthetic to provide an anesthetic effect characterized by sustained local anesthesia after administration to a subject without an initial burst and having a duration of at least about 24 hours after administration. |
地址 |
Cupertino CA US |