发明名称 |
CANCER TREATMENT METHOD |
摘要 |
Invented is a method of treating cancer or a pre-cancerous syndrome in a mammal, including a human, in need thereof which comprises the administration of an effective amount of a non-peptide thrombopoietin (TPO) receptor agonist to such mammal, suitably a human. |
申请公布号 |
US2016235712(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
US201615062750 |
申请日期 |
2016.03.07 |
申请人 |
NOVARTIS AG |
发明人 |
Erickson-Miller Connie L |
分类号 |
A61K31/4152;A61K31/4155;A61K31/496;A61K9/00 |
主分类号 |
A61K31/4152 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a disease state selected from: myelodysplastic syndrome and aplastic anemia, in a mammal in need thereof which comprises the in vivo administration of a therapeutically effective amount of a compound selected from:
3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid; 3-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2-hydroxy-3′-tetrazol-5-ylbiphenyl; and 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridine-2-yl)piperidine-4-carboxylic acid;or a pharmaceutically acceptable salt thereof. |
地址 |
Basel CH |