发明名称 |
Physically stable solid form of a fluoroquinolone |
摘要 |
Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-[1-(methylamino)ethyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.
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申请公布号 |
US5985893(A) |
申请公布日期 |
1999.11.16 |
申请号 |
US19960641569 |
申请日期 |
1996.05.01 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
YU, XUANQIANG;SCHINZER, WILLIAM C.;DUNN, MICHAEL J.;CHAO, ROBERT SHIH-LIANG;ALDRICH, DALE S.;JEGANATHAN, AZHWARSAMY;BERGREN, MICHAEL S. |
分类号 |
A61K31/44;A61K31/4427;A61P31/04;C07D401/04;(IPC1-7):A61K31/47;C07D215/56 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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