发明名称 |
RADIOLABELLED INHIBITORS OF THE GLYCINE 1 TRANSPORTER |
摘要 |
The present invention relates to novel radiolabelled inhibitors of general formula (I) for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. Wherein R1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. It has been found that the radiolabelled compounds of formula (I) may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality.
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申请公布号 |
CA2739869(A1) |
申请公布日期 |
2011.05.14 |
申请号 |
CA20092739869 |
申请日期 |
2009.10.26 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ALBERATI, DANIELA;BORRONI, EDILIO MAURIZIO;HARTUNG, THOMAS;NORCROSS, ROGER;PINARD, EMMANUEL |
分类号 |
C07D405/10;A61K51/00 |
主分类号 |
C07D405/10 |
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