发明名称 |
TDP-43-BINDING POLYPEPTIDES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
摘要 |
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease. |
申请公布号 |
WO2016086320(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015CA51280 |
申请日期 |
2015.12.07 |
申请人 |
UNIVERSITÉ LAVAL |
发明人 |
JULIEN, JEAN-PIERRE;GRAVEL, CLAUDE;POZZI, SILVIA |
分类号 |
C07K16/18;A61K39/395;A61P25/16;A61P25/28;C07K16/46;C12N5/10;C12N15/13;C12N15/864 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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