发明名称 |
Methods and agents for the diagnosis and treatment of hepatocellular carcinoma |
摘要 |
The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists. |
申请公布号 |
US9394359(B2) |
申请公布日期 |
2016.07.19 |
申请号 |
US201414336441 |
申请日期 |
2014.07.21 |
申请人 |
CHINA SYNTHETIC RUBBER CORPORATION |
发明人 |
Kao Kuo-Jang;Huang Andrew T. |
分类号 |
A61K39/00;C07K16/18;C07K16/30;A61K39/395;A61K45/06;A61K47/48;A61K38/00 |
主分类号 |
A61K39/00 |
代理机构 |
Hamilton, Brook, Smith & Reynolds, P.C. |
代理人 |
Hamilton, Brook, Smith & Reynolds, P.C. |
主权项 |
1. An isolated nucleic acid encoding:
a) at least one heavy chain amino acid sequence selected from the group consisting of SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:94, SEQ ID NO:96, SEQ ID NO:98, SEQ ID NO:100, and SEQ ID NO:102; b) at least one kappa light chain amino acid sequence selected from the group consisting of SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:104, SEQ ID NO:106, and SEQ ID NO:108; c) at least one heavy chain amino acid sequence selected from the group consisting of SEQ ID NO:74, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:80, SEQ ID NO:82, SEQ ID NO:84, and SEQ ID NO:86; or d) at least one kappa light chain amino acid sequence selected from the group consisting of SEQ ID NO:70, SEQ ID NO:72, SEQ ID NO:88, SEQ ID NO:90, and SEQ ID NO:92. |
地址 |
Taipei TW |