| 主权项 |
1. A VLP free of a viral genome comprising two or more display polypeptides, nucleic acid molecules, polymers of the nucleic acid molecules, lipopolysaccharides, lipopeptides, peptidoglycans and/or small molecules or a portion thereof which are selected from any of:
a. a tumor associated antigen and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; b. a tumor associated antigen and flagellin; c. a tumor associated antigen, flagellin and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; d. a tumor associated antigen and interleukin 15 (IL-15); e. a tumor associated antigen, IL-15 and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; f. a tumor associated antigen, GM-CSF, flagellin, and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; g. a tumor associated antigen and poly (I:C); h. a tumor associated antigen, poly (I:C) and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; i. a tumor associated antigen and one or more Toll-like receptor (TLR) agonists; j. a tumor associated antigen, GM-CSF and IL-15; k. a tumor associated antigen and (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH lipohexapeptide (Pam3CSK4); l. a tumor associated antigen and a lipopolysaccharide (LPS); m. a tumor associated antigen and 3-(2-methylpropyl)-3,5,8-triazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,7,10,12-hexaen-7-amine (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine or imiquimod); n. a tumor associated antigen, poly (I:C) and imiquimod; o. a tumor associated antigen, Pam3CSK4, flagellin and an immunostimulatory oligonucleotide comprising an unmethylated cytosine; and p. a tumor associated antigen, Pam3CSK4, flagellin, GM-CSF and an immunostimulatory oligonucleotide comprising an unmethylated cytosine. |
