| 发明名称 |
MTOR-independent activator of TFEB for autophagy enhancement and uses thereof |
| 摘要 |
The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed. |
| 申请公布号 |
US2016221907(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201615071222 |
申请日期 |
2016.03.16 |
| 申请人 |
Hong Kong Baptist University |
发明人 |
LI Min;SONG Juxian;YANG Chuanbin;ZENG Yu;MALAMPATI Sandeep;ZHANG Hongjie |
| 分类号 |
C07C49/223;C07C49/255;A61K9/00;C07C49/248;A61K31/12;C07C49/235 |
主分类号 |
C07C49/223 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for enhancing autophagy in cells comprising providing a mono-carbonyl analog of curcumin having a formula ofwherein R is selected from the group consisting of Br, Cl and I. |
| 地址 |
Hong Kong HK |
