发明名称 |
PROCESS FOR PREPARING AN ANTI-CANCER AGENT, 1-((4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)METHYL) CYCLOPROPANAMINE, ITS CRYSTALLINE FORM AND ITS SALTS |
摘要 |
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H- indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. |
申请公布号 |
WO2016179123(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
WO2016US30483 |
申请日期 |
2016.05.03 |
申请人 |
ADVENCHEN PHARMACEUTICALS, LLC;CHEN, Guoqing, Paul |
发明人 |
CHEN, Guoqing, Paul;YAN, Changren |
分类号 |
A61K31/4706;A61K31/4709;C07D215/233;C07D215/42 |
主分类号 |
A61K31/4706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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