Biodegradable metal alloys

摘要

The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

主权项

1. A metal alloy-containing composition, consisting of:
from about 0.5 weight percent to about 4.0 weight percent of yttrium; from greater than zero to about 1.0 weight percent of calcium; from about 0.25 weight percent to about 1.0 weight percent of zirconium; from about 1.0 weight percent to about 4.0 weight percent of strontium; optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum; optionally from about 0.1 weight percent to about 1.0 weight percent of manganese; optionally from about 0.25 weight percent to about 1.0 weight percent of silver; optionally from about 0.1 weight percent to about 1.0 weight percent of cerium; and a balance of magnesium and impurities due to production, based on the total weight of the composition, wherein the metal alloy-containing composition is used to form a biodegradable, medical implant device.