Arrangement for imaging an object including a vessel using magnetic particle imaging

摘要

An arrangement (10) and a method for imaging an object including a vessel (400), using magnetic particle imaging is provided. An image of the vessel (400) is reconstructed based on a known concentration of the magnetic particles (100) within the vessel (400) and on vessel tree data about the progression of said vessel (400). The reconstruction comprises defining cylinder elements (440) around an approximated image and stepwise and separately adapting the radii of the cylinder elements by integrating over the signal intensity of the cylinder elements, wherein the radii are adapted such that the integrated signal intensity over the cylinder elements equals the intensity expected from the known concentration of the magnetic particles in the vessel.

主权项

1. An arrangement for imaging an object including a vessel, within which magnetic particles are present and which is placed in a region of action, comprising:
selection means for generating a magnetic selection field having a pattern in space of a magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action; drive means for changing a position in space of the two sub-zones in the region of action by a magnetic drive field so that a magnetization of the magnetic material changes locally; receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by a change in the position in space of the first sub-zone and the second sub-zone; and processing means operably connected to the receiving means for, responsive to the detection signals, reconstructing an image of the vessel based on a known concentration of the magnetic particles within the vessel and on vessel tree data about a progression of said vessel including
a) transforming the signal intensity of the acquired detection signals into an approximated image of a segment of interest of the vessel based on said vessel tree data,b) defining a cylinder having cylinder elements around said approximated image,c) stepwise and separately adapting the radii of said cylinder elements by integrating over the signal intensity of said cylinder elements, wherein the radii are adapted such that the integrated signal intensity over said cylinder elements equals the intensity expected from the known concentration of the magnetic particles in the vessel,d) reconstructing an improved image by transforming the signal intensity of the acquired detection signals based on the adapted radii of said cylinder elements,e) repeating the steps b) to d) until a predefined condition is fulfilled, wherein said improved image is used as approximated image in the step b), andf) displaying said improved image as cylinders with the determined radii.