| 发明名称 |
RED GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE |
| 摘要 |
Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green GECIs in terms of sensitivity for detecting neural activity, and can be monitored in vivo. The presently-disclosed subject matter further includes a method of monitoring cell activity comprising stimulating a cell comprising a red GECI polypeptide; and detecting fluorescence emitted by the cell. |
| 申请公布号 |
US2016176931(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201514974483 |
申请日期 |
2015.12.18 |
| 申请人 |
Howard Hughes Medical Institute |
发明人 |
Kim Douglas S.;Looger Loren L.;Schreiter Eric R.;Svoboda Karol |
| 分类号 |
C07K14/00;A61K49/00;G01N33/50 |
主分类号 |
C07K14/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid molecule comprising a sequence that encodes a genetically encoded calcium indicator (GECI) polypeptide having at least 95% sequence identity to SEQ ID NO:2 or SEQ ID NO:4. |
| 地址 |
Chevy Chase MD US |
