| 发明名称 |
Preparation and Uses of Obeticholic Acid |
| 摘要 |
The present invention relates to obeticholic acid:;;or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid. |
| 申请公布号 |
US2016176913(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201514947492 |
申请日期 |
2015.11.20 |
| 申请人 |
Intercept Pharmaceuticals, Inc. |
发明人 |
Steiner André;Waenerlund Poulsen Heidi;Jolibois Emilie;Rewolinski Melissa;Gross Ralf;Sharp Emma;Dubas-Fisher Fiona;Eberlin Alex |
| 分类号 |
C07J9/00 |
主分类号 |
C07J9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A crystalline form of obeticholic acid characterized by an X-ray powder diffraction pattern comprising peaks at about 9.5, 12.5 and 16.7 degrees 2-theta. |
| 地址 |
New York NY US |
