SYNTHESIS OF ANTIMICROBIAL SILSESQUIOXANE-SILICA HYBRIDS

摘要

One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a tetraalkoxysilane with two different trialkoxysilanes. Particles are also disclosed that are substantially spherical and have an ordered lamellar internal structure. In addition, polymers prepared from the curable, antimicrobial silsesquioxane-silica hybrids and co-monomers are disclosed.

主权项

1. A method of preparing a silsesquioxane-silica hybrid, comprising:
hydrolytically co-condensing, in the presence of at least one (C1-C3)alcohol and a catalytic amount of an ammonium cation (NH4+), of a tetralkoxysilane of formula I: with a trialkoxysilane of formula II: and with a trialkoxysilane of formula III: wherein said compound of formula II, said compound of formula I, and said compound of formula III are reacted in a molar ratio of about 1:1-32:1, respectively;wherein:A1, A2, A3, and A4 are each independently selected from the group consisting of H, C1-C8alkyl, and trifluoro-substituted (C1-C8)alkyl;Ra is independently a functional group comprising at least one curing group selected from the group consisting of acrylate, methacrylate, (C2-C8)alkenyl, glycidyloxy, epoxy, sulfonate, carboxylate, ester, amino, acrylamide, methacrylamide, isocyanato, amino acid, nucleic acid, and mercapto(C1-C6)alkyl;Rb is independently wherein:Rc is (C1-C2)alkyl;Rd is (C1-C2)alkyl or phenyl;Re is (C6-C22)alkyl;X− is an anion selected from the group consisting of chloride, bromide, fluoride, iodide, sulfonate, and acetate; each Ry is, independently, H, (C1-C8)alkyl, or trifluoro-substituted (C1-C8)alkyl.