Dry powder drug delivery system

摘要

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation.

主权项

1. An inhalation system, comprising:
a dry powder inhaler comprising: a mouthpiece and a container, wherein the container comprises a top and a bottom which are moveable relative to one another by a translational motion to create a first flow path, wherein 20% to 70% of total airflow through the inhaler enters and exits the container, and wherein the container includes a dry powder formulation comprising diketopiperazine particles; and a second flow path wherein 30-80% of total airflow through the inhaler by-passes the container; wherein the second flow path converges with the first flow path at a substantially perpendicular angle, and wherein after a single inhalation from the inhalation system, diketopiperazine in a subject's plasma has an AUC0-∞ greater than 2,300 ng*min/mL per mg of the diketopiperazine content in the dry powder formulation.