| 发明名称 | Hepatocyte-like cells and uses thereof | ||
| 摘要 | The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells. | ||
| 申请公布号 | US9416348(B2) | 申请公布日期 | 2016.08.16 |
| 申请号 | US201113883748 | 申请日期 | 2011.11.04 |
| 申请人 | Shanghai Institutes for Biological Sciences;Chinese Academy of Sciences | 发明人 | Hui Lijian;Huang Pengyu;Wang Xin |
| 分类号 | C12N5/00;C12N5/02;C12N5/071;A61M37/00 | 主分类号 | C12N5/00 |
| 代理机构 | Lee & Hayes, PLLC | 代理人 | Lee & Hayes, PLLC |
| 主权项 | 1. A method of generating hepatocyte-like cells, the method comprising: transducing a p19Arf null fibroblast with a retroviral vector encoding (i) Hnf1α, and (ii) Foxa2, Foxa3, or a combination thereof, thereby producing a transduced cell; and culturing the transduced cell in a medium for a period of time to obtain one or more progeny cells thereof, thereby generating hepatocyte-like cells. | ||
| 地址 | Shanghai CN | ||