Immunoglobulins and variants directed against pathogenic microbes

摘要

Anti-microbial monoclonal antibodies and variant antibodies having a heavy chain constant regions with at least one amino acid substitution are provided. Such antibodies may be used to prevent or treat microbial infections.

主权项

1. An anti-S. aureus variant antibody comprising:
an immunoglobulin heavy chain that differs from that of an unmodified parent anti-S. aureus IgG antibody by at least one amino acid substitution, wherein the unmodified parent anti-S. aureus IgG antibody is an IgG1 isotype comprising SEQ ID NO: 30; and wherein the immunoglobulin heavy chain of the anti-S. aureus variant antibody comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 31, 32, 39-42, and 49-52; wherein the immunoglobulin heavy chain of the anti-S. aureus variant antibody has attenuated non-immune binding to one or more microbial IgBPs as compared that of the unmodified parent anti-S. aureus antibody, and wherein the one or more microbial IgBPs are selected from Sbi, SSL10 and SpA.