Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents

摘要

Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

主权项

1. A method for making a particle comprising:
a. first, covalently linking a monomer and a silyl via an O, N, S, or carboxyl of said monomer to form a silyl functionalized monomer; b. second, covalently linking a drug to said silyl functionalized monomer to form a first drug-silyl functionalized monomer; and c. third, forming a particle from the first drug-silyl functionalized monomer of step b, wherein the drug-silyl functionalized monomer has the structure: