发明名称 |
Methods for treating polycystic kidney disease |
摘要 |
Methods for treating autosomal dominant polycystic kidney disease (ADPKD) are described herein. More particularly, methods described herein relate generally to administering glutaminase1 inhibitors to subjects afflicted with ADPKD. Accordingly, the use and application of compounds or agents that inhibit glutaminase1 for treating ADPKD or for use in a medicament for treating ADPKD are encompassed herein. |
申请公布号 |
US9457016(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201414472967 |
申请日期 |
2014.08.29 |
申请人 |
New York University |
发明人 |
Skolnik Edward;Li Zhai |
分类号 |
A61K31/433;A61K31/501;C07D285/135;A61P31/12;A61K45/06;A61K31/198;A61K31/4155;A61K31/42;A61K31/473;A61K31/4738;A61K31/55;A61K9/00;A61K47/06;A61K9/06;A61K9/08;A61K9/20;A61K9/48 |
主分类号 |
A61K31/433 |
代理机构 |
Klauber & Jackson LLC |
代理人 |
Klauber & Jackson LLC |
主权项 |
1. A method for treating autosomal dominant polycystic kidney disease, the method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of glutaminase 1 activity, wherein the inhibitor of glutaminase 1 activity is bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) or an analog thereof, or a composition of BPTES or an analog thereof. |
地址 |
New York NY US |