Compositions containing berberine or analogs thereof for treating rosacea or red face related skin disorders

摘要

The invention pertains to topical pharmaceutical formulations of berberine and its biologically equivalent analogs, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also pertains to methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogs, such as palmatine.

主权项

1. A method for treating a red face related skin disorder in a patient in need thereof, comprising topically applying to affected skin of said patient a therapeutically effective amount of a pharmaceutical composition comprising at least 0.1% w/w of berberine or pharmaceutically acceptable salt thereof, and wherein the said berberine or said pharmaceutically acceptable salt is the only active component, and wherein the red face related skin disorder is selected from the group consisting of rosacea, acne vulgaris, seborrheic dermatitis, photo dermatitis, contact dermatitis, steroid-induced rosacea-like dermatitis and EGFR inhibitors-induced acneiform dermatitis.