Biodegradeable putty compositions and implant devices, methods, and kits relating to the same

摘要

Disclosed are phospholipid based compositions and implant devices, as well as methods and kits that include such compositions or components thereof. In particular, the present compositions include a polymer component such as a poloxamer or PEG component and a phospholipid component, such as a Phosal. The present compositions may include at least one additional component, such as granules, powder and/or particulates. The present compositions may further include one or more bone graft materials and/or active ingredients. The compositions may be used on their own or incorporated on or in a surgical implant.

主权项

1. A method of preparing a carrier composition comprising:
combining at least one polymer component and at least one phospholipid component to form a carrier composition; combining the carrier composition with one or more active ingredients selected from the group consisting of ceramic beads, particulates, granules, calcium phosphate particles, hydroxyapatite particles, silicated hydroxyapatite particles, bioactive glass particles, cancellous chips, cortical bone chips, and demineralized bone matrix chips; and mixing the carrier composition with blood or bone marrow aspirate.