Methods related to the treatment of neurodegenerative and inflammatory conditions

摘要

The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.

主权项

1. A method of treating a mammal for endotoxic shock by adminstering to the mammal in need thereof an effective amount of a morphinan, wherein the effective amount of a morphinan is 10 pg/kg to 1 μg/kg.