| 摘要 |
Hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines, or combinations thereof, compositions comprising hydrazinopyridazines, fused hydrazinopyridazines, phenylethylhydrazines, or combinations thereof, and methods for using them for the treatment of pain are described. |
| 主权项 |
1. A unit dosage form for treating pain, the unit dosage form comprising one or more fused hydrazinopyridazines in a therapeutically effective amount for treating a patient with a pain disorder, wherein the one or more fused hydrazinopyridazines are the only active ingredients in a therapeutically effective amount for treatment of pain in the unit dosage, and wherein the at least one fused hydrazinopyridazine is a compound of the formula or a pharmaceutically acceptable salt thereof, wherein: R is independently selected in each instance from hydrogen, acyl, or sulfonyl; or alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heteroalkyl, heteroalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl comprising 3-10 ring members, heteroaryl comprising 3-10 ring members, arylalkyl comprising 3-10 ring members, or heteroarylalkyl comprising 3-10 ring members, each of which is optionally substituted; and RA represents three substituents, one of which is selected from the group consisting of hydrogen, halo, hydroxy and derivatives thereof, amino and derivatives thereof, thio and derivatives thereof, acyl, carboxylate or a derivative thereof, hydroxylamino and derivatives thereof, hydrazino and derivatives thereof, sulfinyl or a derivative thereof, or sulfonyl or a derivative thereof; or alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heteroalkyl, heteroalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl comprising 3-10 ring members, heteroaryl comprising 3-10 ring members, arylalkyl comprising 3-10 ring members, or heteroarylalkyl comprising 3-10 ring members, each of which is optionally substituted; and two of RA are taken together with the attached carbons to form an optionally substituted saturated, unsaturated, or aromatic carbocycle or heterocycle. |
