| 主权项 |
1. A method for treating fertility disorders, wherein at least one compound according to formula (I) is administered to a mammal in need of such treatment: wherein W1, W2 denote independently from one another N or CR8,
with the proviso that at least one of W1 or W2 denotes N; R1 denotes —(CY2)n-E-(CY2)n-Het3, —(CY2)n-Cyc-Het3, —(CY2)n—NY-Het3, —(CY2)n—CONH-Het3, —(CY2)n—NHCO-Het3, —(CY2)n—C(Y)(OH)—(CY2)n-Het3, —(CY2)n-Het1, —(CY2)n—CONH-Het1, —(CY2)n—NHCO-Het1, —(CY2)n—Ar, -Cyc-Ar, —(CY2)n—NY—Ar, —(CY2)n—CONH—Ar, —(CY2)n—NHCO—Ar, —(CY2)n—C(Y)(OH)—(CY2)n—Ar, —(CY2)n-Cyc, —(CY2)n—NY-Cyc, —(CY2)n—CONH-Cyc, —(CY2)n—NHCO-Cyc, —(CY2)n—NHCO—NH-Cyc, Y, —(CYR8)n—OY, —(CY2)n—COOY, —(CY2)n—SO2Y, —(CYR8)n—CO—(CY2)n—N(R8)2, —(CY2)n—[C(Y)(OH)]m—(CYR8)n—NY2, [—(CY2)n—O]m—(CYR8)n—NYCOY, —(CY2)n—NYCOOY, —(CY2)n—NYSO2Y, —(CY2)n—NYCON(R8)2, —(CY2)n—NHCO—CH═CH2, —(CY2)n—NHCO—NH—(CY2)n═CH2 or —(CY2)n—CN; R2 denotes Y; R1, R2 together also denote —(CY2)p—NH—(CY2)p—, —(CY2)p—NHCO—(CY2)p—, —(CY2)p—CONH—(CY2)p—, —(CY2)p—N(COA)-(CY2)p—, —(CY2)p—N(COOA)-(CY2)p—, —(CY2)p—C(Y)(Het3)-(CY2)p—, R3 denotes —(CY2)n-Het1, —(CY2)n-Het3, —(CY2)n—Ar, —C(Y)(OY)—Ar, Y or —(CY2)n-Cyc; R4 denotes Y, COY or SO2Y; R5 denotes E-Ar, NY—Ar, Cyc, Y, OY, NYY, NYCOOY, NYCOY, COY, COOY, SO2Y, Het1 or Het3; R6, R7 denote independently from one another H; R6, R7 together also denote —(CY2)p—; R8 denotes Y or Ar; X, E denote independently from one another —(CY2)m—, O, CO, —COO— or SO2; Y denotes H or A; A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms can be replaced independently from one another by Hal, ═O and/or OH; Cyc denotes cycloalkyl having 3-7 C atoms,
in which 1-4 H atoms can be replaced independently from one another by Hal and/or OH; Ar denotes an unsaturated or aromatic mono- or bicyclic carbocycle having 3-10 C atoms,
which can be substituted by at least one substituent selected from the group of A, Hal, —(CY2)n—OY, COOY, CONH2, NHCOY, —(CY2)n—NYCOOY, —(CY2)n—NY2, NO2, SO2Y, SO2NY2, NYSO2Y, —(CY2)n—CN, —(CY2)n-Het2 and Cyc, or which can be fused to Cyc; Het1 denotes an unsaturated or aromatic mono- or bicyclic heterocycle having 1-10 C atoms and 1-4 N, O and/or S atoms,
which can be substituted by at least one substituent selected from the group of Hal, A, Cyc, OY, ═O, COOY, CONH2, NHCOY, —(CY2)n—NY2, SO2Y, SO2NY2, NHSO2Y, CN, Ar and —(CY2)n-Het3; Het2 denotes a saturated or unsaturated monocyclic 5- or 6-membered heterocycle having 1-4 C atoms and 1-4 N, O and/or S atoms,
which can be substituted by A and/or ═O; Het3 denotes a saturated mono- or bicyclic heterocycle having 3-7 C atoms and 1-4 N, O and/or S atoms,
which can be substituted by at least one substituent selected from the group of ═O, A, Hal, —(CY2)n-Cyc, —(CY2)n—OY, COY, COOY, CONY2, NHCOY, —(CY2)n—NY2, CN, SO2Y and —(CY2)n—Ar; Hal denotes F, Cl, Br or I; m, n denote independently from one another 0, 1, 2, 3, 4, 5 or 6; and p denotes 1, 2 or 3;or a physiologically acceptable salt thereof. |
