| 摘要 |
<p>A method for treating or preventing retroviral infection in cells include contacting the cells with novel compounds. Lucifer Yellow and its analogs are coupled to compounds having carbonyl functional groups for reaction with the semicarbazide moiety of Lucifer Yellow to obtain the semicarbazone; alternatively, the naphthyl succinimide moiety of Lucifer Yellow or its analog is bound directly or through an amide linker to at least one aryl residue. Also, a method for inhibiting proliferation of retroviruses in cells includes contacting the cells with precursors to toxic conjugates; the precursors are used in therapeutic compositions. In preferred embodiments, the individual components are Lucifer Yellow and either aldehydes or dialdehydes or derivatives of Lucifer Yellow reacted on an equimolar basis with dialdehydes.</p> |
