SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS

摘要

The present invention is related to new peptide antagonists of a_vß₃ receptor, designed on the basis of the crystal structure of integrin a_vß₃ in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the a_vß₃ receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for a_vß₃-targeted therapy and imaging.