摘要 |
The present invention provides an improved and commercially viable process for the preparation of rimonabant substantially free of amide impurity, namely 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl-4-methyl-pyrazole-3-carboxamide and its pharmaceutically acceptable acid addition salts thereof. Thus, for example, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl-4-methyl-pyrazole-3-carboxylic acid chloride is reacted with 1-minopiperidine in the presence of a base and optionally using a phase transfer catalyst such as tetra-butylammonium bromide in a biphasic reaction medium containing water and a water-immiscible solvent to obtain pure rimonabant. |
申请人 |
HETERO DRUGS LIMITED;PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;RAJI REDDY, RAPOLU;MURALIDHARA REDDY, DASARI;SUBASH CHANDER REDDY, KESIREDDY |
发明人 |
PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;RAJI REDDY, RAPOLU;MURALIDHARA REDDY, DASARI;SUBASH CHANDER REDDY, KESIREDDY |