DIPHENYLOXYALKYLAMINE DERIVATIVES AND ARYLOXYALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE OF SAID PHARMACEUTICAL COMPOSITION FOR TREATING, PREVENTING OR INHIBITING CHRONIC PULMONARY INFLAMMATORY DISEASES AND METHOD FOR TREATING OR PREVENTING SUCH DISEASES

摘要

The present invention relates to diphenyloxyalkylamine derivatives and aryloxyalkylamine derivatives that are structurally analogous to mexiletine, said derivatives having important biological activity and not causing the undesired side effects observed with the prototype, as well as with other drugs from the same therapeutic class as the prototype. The derivatives of the present invention have formulas II and III and are used for treating, preventing or inhibiting pulmonary inflammatory diseases, for example, asthma and chronic obstructive pulmonary disease (COPD).

主权项

1. A compound which is:
(a) a diphenyloxyalkylamine derivative represented by Formula (II):wherein
R2, R3, R4, R5, R6, R7, R8, R9 and R12 are independently H, CH3, OH, CF3, alkoxide, halogen, linear alkyl radical, branched alkyl radical, cyclic alkyl radical, benzyl group, phenyl, alkene, alkyne, hydroxyalkyl, thioalkyl, acetamide, nitro or an oxygen functionality in an acyclic or cyclic system forming a heterocyclic ring; the substituents R10 and R11 are independently H, CH3, linear alkyl radical, branched alkyl radical, cyclic alkyl radical, benzyl group, phenyl, alkene, alkyne, or an oxygen functionality in an acyclic or cyclic system forming a heterocyclic ring; and n is 1 to 4, (b) an aryloxyalkylamine derivative represented by Formula (III),wherein:
R1 and R2 are independently H, CH3, linear alkyl radical, branched alkyl radical, cyclic alkyl radical, benzyl group, phenyl, alkene, alkyne, or an oxygen functionality in an acyclic or cyclic system forming a heterocyclic ring; R3 is CH3, linear alkyl radical, branched alkyl radical, cyclic alkyl radical, benzyl group, phenyl, alkene or alkyne; and R4, R5, R6, R7 and R8 are independently H, CH3, OH, linear alkyl radical, branched alkyl radical, cyclic alkyl radical, benzyl group, phenyl, alkene, alkyne, ether, thioether, halogen, alkylamine, an electron donor group or an electron remover group, or (c) an organic salt or a mineral acid salt of the diphenyloxyalkylamine derivative or the aryloxyalkylamine derivative.