发明名称 |
MACROCYCLIC COMPOUNDS AS IRAK1/4 INHIBITORS AND USES THEREOF |
摘要 |
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. Wherein: Ring A is a 5-membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5- membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; Ring B is a 6-membered aryl, or a 6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; Ring C is a 5-membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5- membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted. |
申请公布号 |
WO2016127025(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
WO2016US16709 |
申请日期 |
2016.02.05 |
申请人 |
MERCK PATENT GMBH;CHEN, XIAOLING;YU, HENRY;LAN, RUOXI;JORAND-LEBRUN, CATHERINE;JOHNSON, THERESA L.;GOUTOPOULOS, ANDREAS |
发明人 |
CHEN, XIAOLING;YU, HENRY;LAN, RUOXI;JORAND-LEBRUN, CATHERINE;JOHNSON, THERESA L.;GOUTOPOULOS, ANDREAS |
分类号 |
C07D487/18;A61P35/00 |
主分类号 |
C07D487/18 |
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