| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a resistance-controlling agent to a fluoroquinolone. <P>SOLUTION: The resistance-controlling mechanism is based, at least in part, on the discovery that inactivation of the AcrAB locus makes even resistant microbial cells hypersusceptible to antibiotics and non-antibiotic drugs. Surprisingly, this is true even among highly resistant microbes which have chromosomal mutations that render them highly resistant to drugs. Accordingly, in one aspect, the invention relates to methods of treating an infection caused by a drug-resistant microbe in a subject by administering a drug to which the microbe is resistant and an inhibitor of an AcrAB-like efflux pump to the subject such that the infection is treated. <P>COPYRIGHT: (C)2011,JPO&INPIT |
