摘要 |
The invention provides new fluorinated cephalosporin antibiotics of Formula I <CHEM> wherein R<a>, R<b>, R<c>, R<d> and R<e>, independently, are H, F or C1-C6 alkyl-(Z)n- group having at least one fluorine substituent; X is O or S; Y is S, O, or -CH2-; Z is O, S, -SO-, or -SO2-; m and n independently are 0 or 1; and R<1> is H, C1-C6-alkyl, phenyl or benzyl, each of which may optionally have up to three substituents selected from halo, C1-C4-alkoxy, phenyl, NO2, C1-C6-alkanoyl, benzoyl, or C1-C6-alkanoyloxy; or a physiologically acceptable salt thereof; provided that: 1) at least one of R<a>, R<b>, R<c>, R<d> or R<e> is other than hydrogen; and 2) when R<e> is F, or one of R<b> or R<d> is CF, at least one of the remaining R<a>, R<b>, R<c>, R<d> or R<e> is other than hydrogen, processes for preparing these compounds and veterinary and pharmaceutical formulations containing a Formula I compound as an active ingredient. |