Promoter variants of the alpha-7 nicotinic acetylcholine receptor

摘要

The present invention is directed to methods and compositions related to alpha7 acetylcholine nicotinic receptor genes, in particular, the human alpha7 nicotinic acetylcholine receptor gene. The human alpha7 nicotinic acetylcholine receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal alpha7 alleles, as well as methods and compositions for development of therapeutics.