| 发明名称 | Fully human antibodies to BTLA | ||
| 摘要 | The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders. | ||
| 申请公布号 | US9346882(B2) | 申请公布日期 | 2016.05.24 |
| 申请号 | US201314031319 | 申请日期 | 2013.09.19 |
| 申请人 | E. R. SQUIBB & SONS, L.L.C. | 发明人 | Mataraza Jennifer Marie;Van Elsas Andrea;Korman Alan J.;Halk Edward L.;Thudium Kent B.;Selby Mark J.;Sproul Timothy W.;Leblanc Heidi N. |
| 分类号 | C07K16/28;C12N15/11;C12N15/79;C12N15/00 | 主分类号 | C07K16/28 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Sloper, Esq. Jill Gorny |
| 主权项 | 1. An isolated nucleic acid comprising a nucleotide sequence encoding heavy and light chain variable regions of an antibody, or antigen binding fragment thereof, wherein the heavy and light variable regions comprise the amino acid sequences set forth in SEQ ID NOs:25 and 32, respectively. | ||
| 地址 | Princeton NJ US | ||