Inhibition of tace activity with cyclic peptides

摘要

A method is provided for inhibiting TACE activity in a human subject, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.

主权项

1. A method of treating rheumatoid arthritis in an animal, comprising:
determining that the animal has rheumatoid arthritis, and administering a pharmacologically acceptable formulation of a θ-defensin to the animal in an amount effective to inhibit TACE activity.