| 发明名称 |
METHOD FOR THE PURIFICATION OF EPOTHILONES VIA CRYSTALLIZATION |
| 摘要 |
The present invention provides a new method of separating epothilones from one another that can be used on an industrial scale for the selective enrichment of epothilone and to provide a crystalline solid of enhanced purity, which can be used for the production of pharmaceutical preparations without using normal or reverse-phase chromatography or any energy input via distillation apparatus, wherein the new method comprises the steps:
a. dissolving a crude containing epothilones in an alkyl ester,b. cooling the solution form a slurry,c. isolating a crystalline solid from the slurry. |
| 申请公布号 |
US2016185793(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201414911404 |
申请日期 |
2014.08.18 |
| 申请人 |
SANDOZ AG |
发明人 |
LUBBE Mathias;SCHICKANEDER Christian;LIMMERT Michael |
| 分类号 |
C07D493/04 |
主分类号 |
C07D493/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of separating an epothilone from a mixture containing epothilone B, comprising the steps:
a. dissolving a crude containing epothilones in an alkyl ester, b. cooling the solution to −15° C. to 15° C. to form a slurry, and c. isolating a crystalline solid containing epothilone B from the said slurry. |
| 地址 |
Basel CH |
