发明名称 |
EXOSOMES SOURCED FROM GRANULOCYTE MYELOID-DERIVED SUPPRESSOR CELL AND APPLICATION THEREOF |
摘要 |
Provided are exosomes sourced from a granulocyte myeloid-derived suppressor cell and an application thereof. The exosomes are named as G-MDSC exo. Also provided is a use of the exosomes in preparing a drug used for suppressing autoimmune diseases. The G-MDSC exo can effectively suppress proliferation of CD4+T cells in vitro, promote induced proliferation of T regulatory (Treg) cells, alleviate foot swelling of model mice having delayed-type hypersensitivity, and suppress attacks of inflammatory bowel disease (IBD) and collagen-induced arthritis (CIA) of the mice. |
申请公布号 |
WO2016127503(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
WO2015CN77902 |
申请日期 |
2015.04.30 |
申请人 |
JIANGSU UNIVERSITY |
发明人 |
WANG, Shengjun;WANG, Yungang;TIAN, Jie;RUI, Ke;MA, Jie;MA, Bin;TANG, Xinyi;XU, Huaxi |
分类号 |
C12N5/078;A61K35/15;A61P19/02;A61P29/00;A61P37/02;A61P37/08 |
主分类号 |
C12N5/078 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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