发明名称 |
RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTOR 1 BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS |
摘要 |
The present disclosure relates to protein molecules that specifically bind to receptor tyrosine kinase-like orphan receptor 1 (ROR1), which may have at least one humanized ROR1-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to ROR1 may have a second binding domain that binds to another target. In one embodiment, multispecific polypeptide molecules bind both ROR1-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the ROR1-binding poypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules. |
申请公布号 |
WO2016094873(A3) |
申请公布日期 |
2016.08.18 |
申请号 |
WO2015US65395 |
申请日期 |
2015.12.11 |
申请人 |
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC |
发明人 |
BLANKENSHIP, John, W.;MISHER, Lynda;TAN, Philip |
分类号 |
C07K16/28;A61K39/395;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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