发明名称 |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetasis |
摘要 |
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. |
申请公布号 |
US9422538(B2) |
申请公布日期 |
2016.08.23 |
申请号 |
US201514619713 |
申请日期 |
2015.02.11 |
申请人 |
aTyr Pharma, Inc.;Pangu BioPharma Limited |
发明人 |
Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain P.;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
分类号 |
C07K16/40;C12N9/96;G01N33/68;A61K38/53;C12N9/00;C12N5/071;G01N33/573 |
主分类号 |
C07K16/40 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A pharmaceutical composition, comprising an isolated polynucleotide that encodes a methionyl-tRNA synthetase (MetRS) polypeptide of about 50 to about 100 amino acids in length and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 137, wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide, wherein the polypeptide has an extracellular signaling activity, and wherein the composition is substantially endotoxin-free. |
地址 |
San Diego CA US |