| 摘要 |
PROBLEM TO BE SOLVED: To provide abuse-deterrent pharmaceutical compositions capable of retarding release of the pharmaceutically active components when the pharmaceutical composition is ingested in excess of the intended dose.SOLUTION: An abuse deterrent pharmaceutical composition comprising an immediate release dose form is provided, which comprises: a) a pharmaceutically active ingredient; b) an acid soluble ingredient including cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate in an amount of about 1-50 wt%; and c) a buffering ingredient including one or more of calcium carbonate, sodium bicarbonate, magnesium oxide, tribasic sodium phosphate or combinations thereof, wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested more than three unit dose forms of the composition.SELECTED DRAWING: None |
