Process for production of N-acyl amino acid amide

摘要

There is provided a process for producing an N-acyl amino acid amide, comprising a condensation reaction of an N-acyl amino acid with an amine and/or an ammonia, preferably a primary amine, a secondary amine and/or an ammonia under dehydration in the presence of a boron compound as the catalyst and of an alcohol as an auxiliary solvent. The N-acyl amino acid amide can be produced at a high yield and in a short time. A medium for hylotropic dehydration such as hydrocarbon compounds may optionally additionally be used in the reaction.