COMBINED USE OF IMPDH INHIBITORS WITH TOLL-LIKE RECEPTOR AGONISTS

摘要

The present invention provides a broad spectrum, long lasting, and non toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal and treating diseases such as cancer and autoimmune disease. These agents include TLR-ligands and ligand analogs which induce interferon production, in combination with inhibitors of inosine monophosphate dehydrogenase (IMPDH), that further enhance the induction of interferon production.