KERATIN-BINDING DESMOPLAKIN POLYPEPTIDE SEQUENCES

摘要

The invention relates to novel keratin-binding protein materials and to their production and use. Particularly suitable keratin-binding polypeptides are those sequences that are contained in the human protein desmoplakin or that can be derived from modifications of human desmoplakin polypeptide sequences, such as amino acid insertions, substitutions or deletions. The polypeptide sequence of human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID No: 1, position 2193 to 2481 and its functional equivalents. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 to 2871 and its functional equivalents.