Infused carbohydrate based gel pad for sustained oral transmucosal delivery

摘要

The present invention provides an infused carbohydrate based gel pad comprising: glucose polymer syrup, sugar, a hydrocolloid gelling agent, salt, acid, water and an infusing compound for oral transmucosal delivery wherein the gel pad (i) provides transmucosal delivery of active ingredients of the infusing compound into the bloodstream over a predetermined period of time; and (ii) possesses the property of adhesion to gum line tissue of an oral cavity and lack of adhesion to buccal tissue of the oral cavity. The present invention further provides a method of making the infused carbohydrate based gel.

主权项

1. An infused carbohydrate based gel pad comprising: glucose polymer syrup, sugar, a hydrocolloid gelling agent, salt, acid, water and an infusing compound for oral transmucosal delivery wherein the gel pad (i) provides transmucosal delivery of active ingredients of the infusing compound into the bloodstream over a predetermined period of time; and (ii) possesses the property of adhesion to gum line tissue of an oral cavity for transmucosal delivery of the active ingredients across buccal tissue of the oral cavity into the bloodstream wherein the gel pad is made from the following formulation of ingredients: the glucose polymer syrup at a concentration ranging from about 40% to about 60%; the sugar at a concentration ranging from about 25% to about 45%; the hydrocolloid agent at a concentration ranging from about 1% to about 4%; the salt at a concentration ranging from about 1% to about 7%; the acid at a concentration ranging from about 0.5% to about 3.0%; the water at a concentration ranging from about 8% to about 25% wherein concentrations of the ingredients are all measured based upon total weight of the formulation.