Microneedle Patches, Systems, and Methods

摘要

Embodiments of the present application provide microneedle patches and systems, and methods for use of such patches and systems. In one aspect, a microneedle patch is provided including a tab portion for handling the microneedle patch. In another aspect, a system is provided including a microneedle patch and a tray for housing the microneedle patch. In still another aspect, various indicators providing for providing feedback prior to, during, and after administration of the microneedle patch are provided. Advantageously, the described microneedle patches and systems provide improved handling and ease of application of the microneedle patches to skin for the delivery of therapeutic agents.

主权项

1. A microneedle patch for administration of a substance of interest into a biological tissue, the patch comprising:
a base substrate having a microneedle side and an opposing back side; one or more solid microneedles extending from the microneedle side of the base substrate, wherein the one or more solid microneedles comprise a substance of interest; an adhesive layer; a handle layer affixed to the base substrate, wherein the handle layer comprises a tab portion which extends away from the one or more solid microneedles and permits a person to manually hold the tab portion to manipulate the patch without contacting the one or more solid microneedles; and an indicator connected to the opposing back side of the base substrate, wherein the indicator is integral with the handle layer, is disposed between the opposing back side of the base substrate and the handling layer, or is disposed on an opposing back side of the handle layer opposite the adhesive layer.