摘要 |
PROBLEM TO BE SOLVED: To provide a sterilizable thermogelling pharmaceutical composition that contains local anesthetic in a base form, and is suitable for local administration.SOLUTION: A pharmaceutical composition contains local anesthetic such as lidocaine which is solubilized in polyoxyethylene castor oil and surfactant such as poloxamer for giving thermogelling properties, and furthermore, and contains water, in which pH of the composition is a pKa value of at least the one type or more local anesthetic. The composition contains the anesthetic at sufficiently high concentration and sufficiently high pH where pain can be effectively removed after local administration, can be is easily administered by a commonly used tool, and indicates sufficient cohesiveness for exerting an anesthetic action at an administered portion safely and in a controlled predetermined form.SELECTED DRAWING: Figure 1 |