发明名称 |
Non-human animals having a humanized programmed cell death 1 gene |
摘要 |
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that said non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion). |
申请公布号 |
AU2015276978(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
AU20150276978 |
申请日期 |
2015.06.19 |
申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
Burova, Elena;Mujica, Alexander O.;Lai, Ka-Man Venus;Murphy, Andrew J. |
分类号 |
C07K16/28;A01K67/027;C07K14/705;C12N15/85 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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