| 发明名称 |
DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT |
| 摘要 |
Novel disubstituted bicyclic heterocycles, of which the following are exemplary: (a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole, (b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-aminocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole, (c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole and (d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-indole. These are useful for the treatment of thrombotic disease. |
| 申请公布号 |
EP1100795(A1) |
申请公布日期 |
2001.05.23 |
| 申请号 |
EP19990938353 |
申请日期 |
1999.07.27 |
| 申请人 |
BOEHRINGER INGELHEIM ZENTRALE GMBH |
发明人 |
HAUEL, NORBERT;RIES, UWE;PRIEPKE, HENNING;MIHM, GERHARD;WIENEN, WOLFGANG;STASSEN, JEAN, MARIE;BINDER, KLAUS;ZIMMERMANN, RAINER |
| 分类号 |
A61K31/4184;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/4709;A61K31/4725;A61P7/02;C07D215/38;C07D215/40;C07D235/12;C07D235/14;C07D235/16;C07D235/28;C07D307/81;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/14;C07D413/12;C07D417/12;C07D471/04;(IPC1-7):C07D401/12 |
主分类号 |
A61K31/4184 |
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