METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH CpG-CONTAINING POLYNUCLEOTIDE
摘要
The present invention relates to DNA vaccines useful for the prevention and treatment of ongoing autoimmune diseases. The compositions and methods of the invention feature the CpG oligonucleotide, preferably in a motif flanked by two 5' purines and two 3' pyrimidines. The vaccine may further comprise DNA encoding a specific antigen, or the peptide antigen itself. The invention is exemplified for IDDM.
申请公布号
WO0216549(A3)
申请公布日期
2002.07.18
申请号
WO2001IL00790
申请日期
2001.08.23
申请人
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;COHEN, IRUN, R.;QUINTANA, FRANCISCO, J.